Ontology highlight
ABSTRACT:
SUBMITTER: Doussau F
PROVIDER: S-EPMC5648531 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Doussau Frédéric F Schmidt Hartmut H Dorgans Kevin K Valera Antoine M AM Poulain Bernard B Isope Philippe P
eLife 20171009
The segregation of the readily releasable pool of synaptic vesicles (RRP) in sub-pools that are differentially poised for exocytosis shapes short-term plasticity. However, the frequency-dependent mobilization of these sub-pools is poorly understood. Using slice recordings and modeling of synaptic activity at cerebellar granule cell to Purkinje cell synapses of mice, we describe two sub-pools in the RRP that can be differentially recruited upon ultrafast changes in the stimulation frequency. We s ...[more]