Ontology highlight
ABSTRACT:
SUBMITTER: Colpo GD
PROVIDER: S-EPMC5649455 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Colpo Gabriela Delevati GD Stimming Erin Furr EF Rocha Natalia Pessoa NP Teixeira Antonio Lucio AL
Neural regeneration research 20170901 9
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules prese ...[more]