Ontology highlight
ABSTRACT:
SUBMITTER: Bardot P
PROVIDER: S-EPMC5650055 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Bardot Paul P Vincent Stéphane D SD Fournier Marjorie M Hubaud Alexis A Joint Mathilde M Tora László L Pourquié Olivier O
Development (Cambridge, England) 20170911 20
During development, tightly regulated gene expression programs control cell fate and patterning. A key regulatory step in eukaryotic transcription is the assembly of the pre-initiation complex (PIC) at promoters. PIC assembly has mainly been studied <i>in vitro</i>, and little is known about its composition during development. <i>In vitro</i> data suggest that TFIID is the general transcription factor that nucleates PIC formation at promoters. Here we show that TAF10, a subunit of TFIID and of t ...[more]