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Gender difference of metabolic syndrome and its association with dietary diversity at different ages.

ABSTRACT: Previous research indicated that dietary diversity had favorable association with metabolic syndrome (MetS), and it has not been investigated in China.Adults (aged 18+) with complete dietary and biochemical data were collected from 2009 China Health and Nutrition Survey (n=4308). Dietary diversity was measured by modified Dietary Diversity Score (DDS). MetS was defined by the harmonized criteria. The association between DDS and MetS was investigated by multivariable adjusted logistic regression.An inverse-U shape relationship between MetS risk and age was detected for both genders, and female were more vulnerable than male at old times. More diversified diet decreased the risk of MetS for young female (?18 & ?45), similar trends were detected in serum TGs, abdominal adiposity, blood pressure, and fasting blood glucose (all P<0.05). However, this association reversed for old female (>60) and male adults (>45&?60). Greater DDS was associated with higher serum TGs, and lower HDL-C level for male adults, higher blood pressure for old men, but lower blood pressure and fasting blood glucose in young men (all P<0.05).Male adults and old female had the highest risk of getting MetS. More diversified diet decreased MetS risk for young female, but increased the risk for male adults and old female.

SUBMITTER: Tian X

PROVIDER: S-EPMC5650282 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Gender difference of metabolic syndrome and its association with dietary diversity at different ages.

Tian Xu X Xu Xiaohui X Zhang Kai K Wang Hui H

Oncotarget 20170902 43

<h4>Background</h4>Previous research indicated that dietary diversity had favorable association with metabolic syndrome (MetS), and it has not been investigated in China.<h4>Methods</h4>Adults (aged 18+) with complete dietary and biochemical data were collected from 2009 China Health and Nutrition Survey (<i>n</i>=4308). Dietary diversity was measured by modified Dietary Diversity Score (DDS). MetS was defined by the harmonized criteria. The association between DDS and MetS was investigated by m ...[more]

PMID: 29088727

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Project description:BackgroundA gender difference in hepatocellular carcinoma (HCC) that men have higher incidence than women has long been noted and can be explained by the cross-talk between sex hormones and hepatitis B virus/hepatitis C virus (HBV/HCV). Whether metabolic factors yield similar sexual difference in non-HBV/HCV-HCC remains elusive.MethodsThere were 74 782 hepatitis B surface antigen (HBsAg)/antibody to hepatitis C virus (anti-HCV) negative residents who participated in the Keelung Community-Based Integrated Screening program and were followed in 2000-2007. Incident HCC was identified by linkage to the Taiwan Cancer Registry. Cox proportional hazards regression models were used to estimate the association between metabolic factors and HCC stratified by sex. All statistical tests were 2-sided.ResultsWith 320 829 follow-up person-years, 99 residents developed HCC. The adjusted hazard ratios (aHR) were 2.10 (95% confidence interval [CI] = 1.07 to 4.13) and 3.71 (95% CI = 2.01 to 6.86) for prediabetes and diabetes, respectively, in men. The corresponding adjusted hazard ratios were 1.16 (95% CI = 0.48 to 2.83) and 1.47 (95% CI = 0.65 to 3.34) in women. Compared with normal weight (body mass index [BMI] = 23-25), underweight (BMI < 21, HR = 3.56, 95% CI = 1.18 to 10.8) and overweight (BMI = 25 to <27.3, HR = 3.81, 95% CI = 1.43 to 10.2) were associated with an elevated risk in men. The statistically significant gradient relationship per advanced BMI category was noted in women (aHR = 1.41, 95% CI = 1.07 to 1.87). The HCC-fasting glucose (P = .046) and HCC-BMI (P = .03) associations were statistically significantly modified by sex. Elevated aspartate aminotransferase, aspartate aminotransferase-to-platelet index and fibrosis index, and habitual alcohol consumption were related to HCC only in men, whereas increased alanine aminotransferase and lower platelet levels predicted HCC risk in women.ConclusionsWe found that BMI-HCC associations were U-shape for men and linear for women, and the elevated HCC risk began from glucose impairment in men only. Whether good glycemic and weight control can reduce HCC risk warrants further investigation.

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Gender difference of metabolic syndrome and its association with dietary diversity at different ages.

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Gender difference of metabolic syndrome and its association with dietary diversity at different ages.

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