Ontology highlight
ABSTRACT:
SUBMITTER: Lum KM
PROVIDER: S-EPMC5650530 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Lum Kenneth M KM Sato Yoshiaki Y Beyer Brittney A BA Plaisted Warren C WC Anglin Justin L JL Lairson Luke L LL Cravatt Benjamin F BF
ACS chemical biology 20170920 10
Lipids play critical roles in cell biology, often through direct interactions with proteins. We recently described the use of photoreactive lipid probes combined with quantitative mass spectrometry to globally map lipid-protein interactions, and the effects of drugs on these interactions, in cells. Here, we investigate the broader potential of lipid-based chemical proteomic probes for determining the cellular targets of biologically active small molecules, including natural product derivatives a ...[more]