Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Neuroblastoma
SUBMITTER: Kenneth Lum
LAB HEAD: Benjamin Cravatt
PROVIDER: PXD007570 | Pride | 2017-09-26
REPOSITORIES: Pride
Items per page: 1 - 5 of 303 |
ACS chemical biology 20170920 10
Lipids play critical roles in cell biology, often through direct interactions with proteins. We recently described the use of photoreactive lipid probes combined with quantitative mass spectrometry to globally map lipid-protein interactions, and the effects of drugs on these interactions, in cells. Here, we investigate the broader potential of lipid-based chemical proteomic probes for determining the cellular targets of biologically active small molecules, including natural product derivatives a ...[more]