Ontology highlight
ABSTRACT:
SUBMITTER: Freed DM
PROVIDER: S-EPMC5650921 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cell 20171005 3
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways. Using crystallography and other approaches, we show how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened di ...[more]