Ontology highlight
ABSTRACT:
SUBMITTER: Mudumbi KC
PROVIDER: S-EPMC10835193 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Mudumbi Krishna C KC Burns Eric A EA Schodt David J DJ Petrova Zaritza O ZO Kiyatkin Anatoly A Kim Lucy W LW Mangiacapre Emma M EM Ortiz-Caraveo Irais I Rivera Ortiz Hector H Hu Chun C Ashtekar Kumar D KD Lidke Keith A KA Lidke Diane S DS Lemmon Mark A MA
Cell reports 20231220 1
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase with important roles in many cellular processes as well as in cancer and other diseases. EGF binding promotes EGFR dimerization and autophosphorylation through interactions that are well understood structurally. How these dimers relate to higher-order EGFR oligomers seen in cell membranes, however, remains unclear. Here, we used single-particle tracking (SPT) and Förster resonance energy transfer imaging to examine how eac ...[more]