Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.
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ABSTRACT:
SUBMITTER: Yulyaningsih E
PROVIDER: S-EPMC5651178 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.
Yulyaningsih Ernie E Rudenko Ivan A IA Valdearcos Martin M Dahlén Emma E Vagena Eirini E Chan Alvin A Alvarez-Buylla Arturo A Vaisse Christian C Koliwad Suneil K SK Xu Allison W AW
Cell reports 20170601 11
Neurons expressing agouti-related protein (AgRP) are essential for feeding. The majority of these neurons are located outside the blood-brain barrier (BBB), allowing them to directly sense circulating metabolic factors. Here, we show that, in adult mice, AgRP neurons outside the BBB (AgRP<sup>OBBB</sup>) were rapidly ablated by peripheral administration of monosodium glutamate (MSG), whereas AgRP neurons inside the BBB and most proopiomelanocortin (POMC) neurons were spared. MSG treatment induce ...[more]
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