Impact of hormonal contraception and weight loss on high-density lipoprotein cholesterol efflux and lipoprotein particles in women with polycystic ovary syndrome.

ABSTRACT:

Objective

To study the effects of oral contraceptive pills (OCP), the first-line treatment for PCOS, on high-density lipoprotein cholesterol (HDL-C) function (reverse cholesterol efflux capacity) and lipoprotein particles measured using nuclear magnetic resonance spectroscopy in obese women.

Design

Secondary analysis of a randomized controlled trial (OWL-PCOS) of OCP or Lifestyle (intensive Lifestyle modification) or Combined (OCP + Lifestyle) treatment groups for 16 weeks.

Patients

Eighty-seven overweight/obese women with PCOS at two academic centres.

Measurements

Change in HDL-C efflux capacity and lipoprotein particles.

Results

High-density lipoprotein cholesterol efflux capacity increased significantly at 16 weeks in the OCP group [0·11; 95% confiden

SUBMITTER: Dokras A 

PROVIDER: S-EPMC5651984 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature