Ontology highlight
ABSTRACT:
SUBMITTER: Wang JT
PROVIDER: S-EPMC5653238 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Wang Jennifer T JT Kong Dong D Hoerner Christian R CR Loncarek Jadranka J Stearns Tim T
eLife 20170914
Centrioles are composed of long-lived microtubules arranged in nine triplets. However, the contribution of triplet microtubules to mammalian centriole formation and stability is unknown. Little is known of the mechanism of triplet microtubule formation, but experiments in unicellular eukaryotes indicate that delta-tubulin and epsilon-tubulin, two less-studied tubulin family members, are required. Here, we report that centrioles in delta-tubulin and epsilon-tubulin null mutant human cells lack tr ...[more]