In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.
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ABSTRACT:
SUBMITTER: Kessing CF
PROVIDER: S-EPMC5653276 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.
Kessing Cari F CF Nixon Christopher C CC Li Chuan C Tsai Perry P Takata Hiroshi H Mousseau Guillaume G Ho Phong T PT Honeycutt Jenna B JB Fallahi Mohammad M Trautmann Lydie L Garcia J Victor JV Valente Susana T ST
Cell reports 20171001 3
HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a "block-and-lock" functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA). HIV-1 transcriptional inhibitors could block ongoing viremia during antiretroviral therapy (ART), locking the HIV promoter in persistent latency. We investigated this hypothesis in human CD4<sup>+</sup> T cells isolated from aviremic individuals. Combining dC ...[more]
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