Ontology highlight
ABSTRACT:
SUBMITTER: Murthy S
PROVIDER: S-EPMC5653296 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Murthy Shubha S Koval Olha M OM Ramiro Diaz Juan M JM Kumar Santosh S Nuno Daniel D Scott Jason A JA Allamargot Chantal C Zhu Linda J LJ Broadhurst Kim K Santhana Velarchana V Kutschke William J WJ Irani Kaikobad K Lamping Kathryn G KG Grumbach Isabella M IM
PloS one 20171023 10
The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine kinase important in transducing intracellular Ca2+ signals. While in vitro data regarding the role of CaMKII in the regulation of endothelial nitric oxide synthase (eNOS) are contradictory, its role in endothelial function in vivo remains unknown. Using two novel transgenic models to express CaMKII inhibitor peptides selectively in endothelium, we examined the effect of CaMKII on eNOS activation, NO pr ...[more]