Ontology highlight
ABSTRACT:
SUBMITTER: Hoerndli FJ
PROVIDER: S-EPMC4409548 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Hoerndli Frédéric J FJ Wang Rui R Mellem Jerry E JE Kallarackal Angy A Brockie Penelope J PJ Thacker Colin C Madsen David M DM Maricq Andres V AV
Neuron 20150402 2
Excitatory glutamatergic synaptic transmission is critically dependent on maintaining an optimal number of postsynaptic AMPA receptors (AMPARs) at each synapse of a given neuron. Here, we show that presynaptic activity, postsynaptic potential, voltage-gated calcium channels (VGCCs) and UNC-43, the C. elegans homolog of CaMKII, control synaptic strength by regulating motor-driven AMPAR transport. Genetic mutations in unc-43, or spatially and temporally restricted inactivation of UNC-43/CaMKII, re ...[more]