Ontology highlight
ABSTRACT:
SUBMITTER: da Rocha AM
PROVIDER: S-EPMC5653750 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
da Rocha André Monteiro AM Campbell Katherine K Mironov Sergey S Jiang Jiang J Mundada Lakshmi L Guerrero-Serna Guadalupe G Jalife José J Herron Todd J TJ
Scientific reports 20171023 1
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer a novel in vitro platform for pre-clinical cardiotoxicity and pro-arrhythmia screening of drugs in development. To date hiPSC-CMs used for cardiotoxicity testing display an immature, fetal-like cardiomyocyte structural and electrophysiological phenotype which has called into question the applicability of hiPSC-CM findings to the adult heart. The aim of the current work was to determine the effect of cardiomyocyte matura ...[more]