Ontology highlight
ABSTRACT:
SUBMITTER: Sivaramakrishnan P
PROVIDER: S-EPMC5654330 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nature 20171004 7675
Homologous recombination repairs DNA double-strand breaks and must function even on actively transcribed DNA. Because break repair prevents chromosome loss, the completion of repair is expected to outweigh the transcription of broken templates. However, the interplay between DNA break repair and transcription processivity is unclear. Here we show that the transcription factor GreA inhibits break repair in Escherichia coli. GreA restarts backtracked RNA polymerase and hence promotes transcription ...[more]