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Remote functionalization of hydrocarbons with reversibility enhanced stereocontrol.

ABSTRACT: Remote functionalization of hydrocarbons could be achieved through successive zirconocene-mediated allylic C-H bond activations followed by a selective C-C bond cleavage. Determination of the reaction mechanism by density functional theory (DFT) calculations shows that the high stereocontrol observed in this process results from a large number of energetically accessible equilibria feeding a preferred reactive channel that leads to the major product. A distinctive consequence of this pattern is that stereoselectivity is enhanced upon heating.

SUBMITTER: Vasseur A

PROVIDER: S-EPMC5654413 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Remote functionalization of hydrocarbons with reversibility enhanced stereocontrol.

Vasseur Alexandre A Perrin Lionel L Eisenstein Odile O Marek Ilan I

Chemical science 20150303 5

Remote functionalization of hydrocarbons could be achieved through successive zirconocene-mediated allylic C-H bond activations followed by a selective C-C bond cleavage. Determination of the reaction mechanism by density functional theory (DFT) calculations shows that the high stereocontrol observed in this process results from a large number of energetically accessible equilibria feeding a preferred reactive channel that leads to the major product. A distinctive consequence of this pattern is ...[more]

PMID: 29142680

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