Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development.
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ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC5655024 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development.
Xu Congyu C Yu Linjie L Hou Jinxing J Jackson Rosemary J RJ Wang He H Huang Chaoli C Liu Tingting T Wang Qihui Q Zou Xiaochuan X Morris Richard G RG Spires-Jones Tara L TL Yang Zhongzhou Z Yin Zhenyu Z Xu Yun Y Chen Guiquan G
Frontiers in cellular neuroscience 20171020
Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study <i>in vivo</i> function of PDK1 in neuron survival during cortical development, we generate forebrain-specific <i>PDK1</i> conditional knockout (cKO) mice. We demonstrate that <i>PDK1</i> cKO mice display striking neuron loss and increased apoptosis. We report that <i>PDK1</i> cKO mice exhibit deficits on several behavioral tasks. Moreover, <i>PDK1</i> cKO mice show decreased activities f ...[more]
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