Ontology highlight
ABSTRACT:
SUBMITTER: McBride JM
PROVIDER: S-EPMC5655070 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
McBride Jacqueline M JM Lim Jeremy J JJ Burgess Tracy T Deng Rong R Derby Michael A MA Maia Mauricio M Horn Priscilla P Siddiqui Omer O Sheinson Daniel D Chen-Harris Haiyin H Newton Elizabeth M EM Fillos Dimitri D Nazzal Denise D Rosenberger Carrie M CM Ohlson Maikke B MB Lambkin-Williams Rob R Fathi Hosnieh H Harris Jeffrey M JM Tavel Jorge A JA
Antimicrobial agents and chemotherapy 20171024 11
MHAA4549A, a human monoclonal antibody targeting the hemagglutinin stalk region of influenza A virus (IAV), is being developed as a therapeutic for patients hospitalized with severe IAV infection. The safety and efficacy of MHAA4549A were assessed in a randomized, double-blind, placebo-controlled, dose-ranging study in a human IAV challenge model. One hundred healthy volunteers were inoculated with A/Wisconsin/67/2005 (H3N2) IAV and, 24 to 36 h later, administered a single intravenous dose of ei ...[more]