Unknown

Dataset Information

0

Heterogeneous Genetic Location of mcr-1 in Colistin-Resistant Escherichia coli Isolates from Humans and Retail Chicken Meat in Switzerland: Emergence of mcr-1-Carrying IncK2 Plasmids.


ABSTRACT: We characterized the genetic environment of mcr-1 in colistin-resistant Escherichia coli strains isolated in Switzerland during 2014 to 2016 from humans (n = 3) and chicken meat (n = 6). Whole-genome and plasmid sequencing identified the mcr-1 gene integrated in IncX4 (of which, one strain carried the mcr-1.2 variant), IncI2, IncHI2, and novel IncK2 plasmids (overall, n = 7), as well as in the bacterial chromosome (n = 2) in single or duplicate copies. Our study supports the easy mobilization of mcr-1 across diverse genetic locations.

SUBMITTER: Dona V 

PROVIDER: S-EPMC5655086 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Heterogeneous Genetic Location of <i>mcr-1</i> in Colistin-Resistant Escherichia coli Isolates from Humans and Retail Chicken Meat in Switzerland: Emergence of <i>mcr-1</i>-Carrying IncK2 Plasmids.

Donà Valentina V   Bernasconi Odette J OJ   Pires João J   Collaud Alexandra A   Overesch Gudrun G   Ramette Alban A   Perreten Vincent V   Endimiani Andrea A  

Antimicrobial agents and chemotherapy 20171024 11


We characterized the genetic environment of <i>mcr-1</i> in colistin-resistant <i>Escherichia coli</i> strains isolated in Switzerland during 2014 to 2016 from humans (<i>n</i> = 3) and chicken meat (<i>n</i> = 6). Whole-genome and plasmid sequencing identified the <i>mcr-1</i> gene integrated in IncX4 (of which, one strain carried the <i>mcr-1.2</i> variant), IncI2, IncHI2, and novel IncK2 plasmids (overall, <i>n</i> = 7), as well as in the bacterial chromosome (<i>n</i> = 2) in single or dupli  ...[more]

Similar Datasets

| S-EPMC7698652 | biostudies-literature
| S-EPMC5404526 | biostudies-literature
| S-EPMC5563067 | biostudies-other
| PRJEB44904 | ENA
| S-EPMC7407033 | biostudies-literature
| S-EPMC5487637 | biostudies-literature
| S-EPMC9891347 | biostudies-literature
| S-EPMC6780365 | biostudies-literature
| PRJEB33495 | ENA
| S-EPMC7913130 | biostudies-literature