Ontology highlight
ABSTRACT:
SUBMITTER: Zhou H
PROVIDER: S-EPMC5655238 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Zhou Hang H Luo Wei W Zeng Chao C Zhang Yu Y Wang Liyang L Yao Wenxiu W Nie Chunlai C
Oncotarget 20170823 46
The crosstalk between apoptosis and autophagy contributes to tumorigenesis and cancer therapy. The process by which BetA (betulinic acid), a naturally occurring triterpenoid, regulates apoptosis and autophagy as a cancer therapy is unclear. In this study, we show for the first time that protein phosphatase 2A (PP2A) acts as a switch to regulate apoptosis and autophagic cell death mediated by BetA. Under normal conditions, caspase-3 is activated by the mitochondrial pathway upon BetA treatment. A ...[more]