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Current Perspective in the Discovery of Anti-aging Agents from Natural Products.

ABSTRACT: Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special resource advantage and with few side effect. Recently, many compounds or extracts from natural products slowing aging and extending lifespan have been reported. Here we summarized these compounds or extracts and their mechanisms in increasing longevity of C. elegans or other species, and the prospect in developing anti-aging medicine from natural products.

SUBMITTER: Ding AJ

PROVIDER: S-EPMC5655361 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Current Perspective in the Discovery of Anti-aging Agents from Natural Products.

Ding Ai-Jun AJ Zheng Shan-Qing SQ Huang Xiao-Bing XB Xing Ti-Kun TK Wu Gui-Sheng GS Sun Hua-Ying HY Qi Shu-Hua SH Luo Huai-Rong HR

Natural products and bioprospecting 20170531 5

Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special ...[more]

PMID: 28567542

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