Dataset Information

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder.

ABSTRACT:

Background

Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder.

Methods

In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent ¹⁸ F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included ¹⁸ F-fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD-related pattern expression z-scores were computed from all PET scans.

Results

PD-related pattern expression was higher in idiopathic REM sleep behavior disorder subjects compared with controls (P?=?0.048), but lower compared with PD (P?=?0.001) and dementia with Lewy bodies (P?ConclusionPD-related pattern expression, dopamine transporter binding, and olfaction may provide complementary information for predicting phenoconversion. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

SUBMITTER: Meles SK

PROVIDER: S-EPMC5655750 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Publications

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder.

Meles Sanne K SK Vadasz David D Renken Remco J RJ Sittig-Wiegand Elisabeth E Mayer Geert G Depboylu Candan C Reetz Kathrin K Overeem Sebastiaan S Pijpers Angelique A Reesink Fransje E FE van Laar Teus T Heinen Lisette L Teune Laura K LK Höffken Helmut H Luster Marcus M Kesper Karl K Adriaanse Sofie M SM Booij Jan J Leenders Klaus L KL Oertel Wolfgang H WH

Movement disorders : official journal of the Movement Disorder Society 20170722 10

<h4>Background</h4>Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder.<h4>Methods</h4>In this ...[more]

PMID: 28734065

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Dataset Information

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder.

Background

Methods

Results

Publications

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder.

Similar Datasets

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