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Chloromethyl-triazole: a new motif for site-selective pseudo-acylation of proteins.

ABSTRACT: Rapid, site-selective modification of cysteine residues with chloromethyl-triazole derivatives generates pseudo-acyl sLys motifs, mimicking important post-translational modifications. Near-native biotinylation of peptide and protein substrates is shown to be site-selective and modified histone H4 retains functional activity.

SUBMITTER: Brewster RC 

PROVIDER: S-EPMC5656099 | biostudies-literature |

REPOSITORIES: biostudies-literature

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