Ontology highlight
ABSTRACT:
SUBMITTER: Martos-Maldonado MC
PROVIDER: S-EPMC6098153 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180817 1
Methods for site-selective chemistry on proteins are in high demand for the synthesis of chemically modified biopharmaceuticals, as well as for applications in chemical biology, biosensors and more. Inadvertent N-terminal gluconoylation has been reported during expression of proteins with an N-terminal His tag. Here we report the development of this side-reaction into a general method for highly selective N-terminal acylation of proteins to introduce functional groups. We identify an optimized N ...[more]