B-cell-targeted therapies in relapsing forms of MS.
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ABSTRACT:
SUBMITTER: Dubey D
PROVIDER: S-EPMC5656409 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
B-cell-targeted therapies in relapsing forms of MS.
Dubey Divyanshu D Forsthuber Thomas T Flanagan Eoin P EP Pittock Sean J SJ Stüve Olaf O
Neurology(R) neuroimmunology & neuroinflammation 20171023 6
In recent years, there has been a significant increase in the therapeutic options available for the management of relapsing forms of MS. Therapies primarily targeting B cells, including therapeutic anti-CD20 monoclonal antibodies, have been evaluated in phase I, phase II, and phase III clinical trials. Results of these trials have shown their efficacy and relatively tolerable adverse effect profiles, suggesting a favorable benefit-to-risk ratio. In this review, we discuss the pathogenic role of ...[more]
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