Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed A
PROVIDER: S-EPMC5656679 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ahmed Amel A Wang Lei-Lei LL Abdelmaksoud Safaa S Aboelgheit Amal A Saeed Safaa S Zhang Chun-Li CL
Scientific reports 20171025 1
Retinal ischemia-reperfusion (IR) injury causes irreversible loss of neurons and ultimately leads to permanent visual impairment and blindness. The cellular response under this pathological retinal condition is less clear. Using genetically modified mice, we systematically examined the behavior of microglia/macrophages after injury. We show that IR leads to activation of microglia/macrophages indicated by migration and proliferation of resident microglia and recruitment of circulating monocytes. ...[more]