Ontology highlight
ABSTRACT:
SUBMITTER: Roundtree IA
PROVIDER: S-EPMC5657247 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Roundtree Ian A IA Evans Molly E ME Pan Tao T He Chuan C
Cell 20170601 7
Over 100 types of chemical modifications have been identified in cellular RNAs. While the 5' cap modification and the poly(A) tail of eukaryotic mRNA play key roles in regulation, internal modifications are gaining attention for their roles in mRNA metabolism. The most abundant internal mRNA modification is N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), and identification of proteins that install, recognize, and remove this and other marks have revealed roles for mRNA modification in nearly eve ...[more]