Dataset Information

Versatile Core-Shell Nanoparticle@Metal-Organic Framework Nanohybrids: Exploiting Mussel-Inspired Polydopamine for Tailored Structural Integration.

ABSTRACT: We report a versatile strategy based on the use of multifunctional mussel-inspired polydopamine for constructing well-defined single-nanoparticle@metal-organic framework (MOF) core-shell nanohybrids. The capability of polydopamine to form a robust conformal coating on colloidal substrates of any composition and to direct the heterogeneous nucleation and growth of MOFs makes it possible for customized structural integration of a broad range of inorganic/organic nanoparticles and functional MOFs. Furthermore, the unique redox activity of polydopamine adds additional possibilities to tailor the functionalities of the nanohybrids by sandwiching plasmonic/catalytic metal nanostructures between the core and shell via localized reduction. The core-shell nanohybrids, with the molecular sieving effect of the MOF shell complementing the intrinsic properties of nanoparticle cores, represent a unique class of nanomaterials of considerable current interest for catalysis, sensing, and nanomedicine.

SUBMITTER: Zhou J

PROVIDER: S-EPMC5660865 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Versatile Core-Shell Nanoparticle@Metal-Organic Framework Nanohybrids: Exploiting Mussel-Inspired Polydopamine for Tailored Structural Integration.

Zhou Jiajing J Wang Peng P Wang Chenxu C Goh Yi Ting YT Fang Zheng Z Messersmith Phillip B PB Duan Hongwei H

ACS nano 20150615 7

We report a versatile strategy based on the use of multifunctional mussel-inspired polydopamine for constructing well-defined single-nanoparticle@metal-organic framework (MOF) core-shell nanohybrids. The capability of polydopamine to form a robust conformal coating on colloidal substrates of any composition and to direct the heterogeneous nucleation and growth of MOFs makes it possible for customized structural integration of a broad range of inorganic/organic nanoparticles and functional MOFs. ...[more]

PMID: 26061627

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Project description:Most photothermal converting systems are not biodegradable, which bring the uneasiness when they are administered into human body due to the uncertainty of their fate. Hereby, we developed a mussel-inspired PLGA/polydopamine core-shell nanoparticle for cancer photothermal and chemotherapy. With the help of an anti-EGFR antibody, the nanoparticle could effectively enter head and neck cancer cells and convert near-infrared light to heat to trigger drug release from PLGA core for chemotherapy as well as ablate tumors by the elevated temperature. Due to the unique nanoparticle concentration dependent peak working-temperature nature, an overheating or overburn situation can be easily prevented. Since the nanoparticle was retained in the tumor tissue and subsequently released its payload inside the cancer cells, no any doxorubicin-associated side effects were detected. Thus, the developed mussel-inspired PLGA/polydopamine core-shell nanoparticle could be a safe and effective tool for the treatment of head and neck cancer.Statement of significanceThe described EGFR targeted PLGA/polydopamine core-shell nanoparticle (PLGA/PD NP) is novel in the following aspects: Different from most photothermal converting nanomaterials, PLGA/PD NP is biodegradable, which eliminates the long-term safety concerns thwarting the clinical application of photothermal therapy. Different from most photothermal nanomaterials, upon NIR irradiation, PLGA/PD NP quickly heats its surrounding environment to a NP concentration dependent peak working temperature and uniquely keeps that temperature constant through the duration of light irradiation. Due to this unique property an overheating or overburn situation for the adjacent healthy tissue can be easily avoided. The PLGA/PD NP releases its payload through detaching PD shell under NIR laser irradiation. The EGFR-targeted doxorubicin-loaded PLGA/PD NP effectively eradicate head and neck tumor in vivo through the synergism of photothermal therapy and chemotherapy while not introducing doxorubicin associated cardiotoxicity.

Dataset Information

Versatile Core-Shell Nanoparticle@Metal-Organic Framework Nanohybrids: Exploiting Mussel-Inspired Polydopamine for Tailored Structural Integration.

Publications

Versatile Core-Shell Nanoparticle@Metal-Organic Framework Nanohybrids: Exploiting Mussel-Inspired Polydopamine for Tailored Structural Integration.

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