Dataset Information

Mussel-Inspired Adhesive Polydopamine-Functionalized Hyaluronic Acid Hydrogel with Potential Bacterial Inhibition.

ABSTRACT: Hyaluronic acid (HA)-based hydrogels have been receiving increasing attention for wound management. However, pure HA hydrogels usually exhibit weak mechanical strength and poor anti-infection. Herein, a hybrid HA-based hydrogel (PDA-HA) comprised of polydopamine (PDA) and thiolated hyaluronic acid (HA-SH) is developed based on the Michael addition reaction. The introduction of PDA into HA hydrogel can decrease the critical gel concentration, improve the cell affinity and tissue adhesion, as well as endow the hydrogel with efficient free-radical scavenging ability. Combining the merits of good biocompatibility and moist environment from HA hydrogel with excellent tissue adhesiveness and free radical scavenging capability from PDA, this cross-linked PDA-HA hybrid hydrogel exhibits great potential for creating antimicrobial wound medical dressings.

SUBMITTER: Yu QH

PROVIDER: S-EPMC7001117 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Mussel-Inspired Adhesive Polydopamine-Functionalized Hyaluronic Acid Hydrogel with Potential Bacterial Inhibition.

Yu Qi-Hang QH Zhang Chen-Ming CM Jiang Zhi-Wei ZW Qin Si-Yong SY Zhang Ai-Qing AQ

Global challenges (Hoboken, NJ) 20191118 2

Hyaluronic acid (HA)-based hydrogels have been receiving increasing attention for wound management. However, pure HA hydrogels usually exhibit weak mechanical strength and poor anti-infection. Herein, a hybrid HA-based hydrogel (PDA-HA) comprised of polydopamine (PDA) and thiolated hyaluronic acid (HA-SH) is developed based on the Michael addition reaction. The introduction of PDA into HA hydrogel can decrease the critical gel concentration, improve the cell affinity and tissue adhesion, as well ...[more]

PMID: 32042445

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Project description:Most photothermal converting systems are not biodegradable, which bring the uneasiness when they are administered into human body due to the uncertainty of their fate. Hereby, we developed a mussel-inspired PLGA/polydopamine core-shell nanoparticle for cancer photothermal and chemotherapy. With the help of an anti-EGFR antibody, the nanoparticle could effectively enter head and neck cancer cells and convert near-infrared light to heat to trigger drug release from PLGA core for chemotherapy as well as ablate tumors by the elevated temperature. Due to the unique nanoparticle concentration dependent peak working-temperature nature, an overheating or overburn situation can be easily prevented. Since the nanoparticle was retained in the tumor tissue and subsequently released its payload inside the cancer cells, no any doxorubicin-associated side effects were detected. Thus, the developed mussel-inspired PLGA/polydopamine core-shell nanoparticle could be a safe and effective tool for the treatment of head and neck cancer. STATEMENT OF SIGNIFICANCE:The described EGFR targeted PLGA/polydopamine core-shell nanoparticle (PLGA/PD NP) is novel in the following aspects: Different from most photothermal converting nanomaterials, PLGA/PD NP is biodegradable, which eliminates the long-term safety concerns thwarting the clinical application of photothermal therapy. Different from most photothermal nanomaterials, upon NIR irradiation, PLGA/PD NP quickly heats its surrounding environment to a NP concentration dependent peak working temperature and uniquely keeps that temperature constant through the duration of light irradiation. Due to this unique property an overheating or overburn situation for the adjacent healthy tissue can be easily avoided. The PLGA/PD NP releases its payload through detaching PD shell under NIR laser irradiation. The EGFR-targeted doxorubicin-loaded PLGA/PD NP effectively eradicate head and neck tumor in vivo through the synergism of photothermal therapy and chemotherapy while not introducing doxorubicin associated cardiotoxicity.

Dataset Information

Mussel-Inspired Adhesive Polydopamine-Functionalized Hyaluronic Acid Hydrogel with Potential Bacterial Inhibition.

Publications

Mussel-Inspired Adhesive Polydopamine-Functionalized Hyaluronic Acid Hydrogel with Potential Bacterial Inhibition.

Similar Datasets

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