Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study.

ABSTRACT:

Background

The rise in incidence of Alzheimer's disease (AD) has led to efforts to advance early detection of the disease during its preclinical stages. To achieve this, the field needs to develop more sensitive cognitive tests that relate to biological markers of disease pathology. Failure to recover from proactive interference (frPSI) is one such cognitive marker that is associated with volumetric reductions in the hippocampus, precuneus, and other AD-prone regions, and to amyloid load in the brain.

Objective

The current study attempted to replicate and extend our previous findings that frPSI is a sensitive marker of early AD, and related to a unique pattern of volumetric loss in AD prone areas.

Methods

Three different memory measures were examined relative to volum

SUBMITTER: Loewenstein DA 

PROVIDER: S-EPMC5660922 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature