Ontology highlight
ABSTRACT:
SUBMITTER: Epp JR
PROVIDER: S-EPMC4773435 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
Epp Jonathan R JR Silva Mera Rudy R Köhler Stefan S Josselyn Sheena A SA Frankland Paul W PW
Nature communications 20160226
Established memories may interfere with the encoding of new memories, particularly when existing and new memories overlap in content. By manipulating levels of hippocampal neurogenesis, here we show that neurogenesis regulates this form of proactive interference. Increasing hippocampal neurogenesis weakens existing memories and, in doing so, facilitates the encoding of new, conflicting (but not non-conflicting) information in mice. Conversely, decreasing neurogenesis stabilizes existing memories ...[more]