Ontology highlight
ABSTRACT:
SUBMITTER: Morales L
PROVIDER: S-EPMC5662013 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cell host & microbe 20170216 3
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pathology. To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced RNAs from the lungs of infected mice and discovered three 18-22 nt small viral RNAs (svRNAs). The three svRNAs were derived from the nsp3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV. Biogenesis of CoV s ...[more]