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Endocan expression is correlated with poor progression-free survival in patients with pancreatic neuroendocrine tumors.


ABSTRACT: Endocan expression has been reported to be associated with aggressive tumor progression and poor outcomes in various cancers, such as breast cancer, renal cell cancer, lung cancer, gastric cancer, and pituitary adenomas. However, the prognostic significance of endocan in neuroendocrine tumors remains unknown. Thus, the aim of this study was to determine the correlation between endocan expression in pancreatic neuroendocrine tumor (PNET) tissues and progression-free survival. This study included 73 patients with confirmed PNETs who were treated in a single tertiary center in north Taiwan between 1992 and 2015. Immunohistochemical endocan expression and microvessel density (MVD) were examined, and the relationships between these parameters and other clinicopathological characteristics were analyzed. The abovementioned patients were divided into groups according to their endocan expression levels (?1% or <1%) and median MVDs. Negative endocan expression (P?=?.002) and a high MVD (P?

SUBMITTER: Lin LY 

PROVIDER: S-EPMC5662320 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Endocan expression is correlated with poor progression-free survival in patients with pancreatic neuroendocrine tumors.

Lin Liang-Yu LY   Yeh Yi-Chen YC   Chu Chia-Huei CH   Won Justin G S JGS   Shyr Yi-Ming YM   Chao Yee Y   Li Chung-Pin CP   Wang Shin-E SE   Chen Ming-Huang MH  

Medicine 20171001 41


Endocan expression has been reported to be associated with aggressive tumor progression and poor outcomes in various cancers, such as breast cancer, renal cell cancer, lung cancer, gastric cancer, and pituitary adenomas. However, the prognostic significance of endocan in neuroendocrine tumors remains unknown. Thus, the aim of this study was to determine the correlation between endocan expression in pancreatic neuroendocrine tumor (PNET) tissues and progression-free survival. This study included  ...[more]

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