Unknown

Dataset Information

0

Low expression of ARHI is associated with shorter progression-free survival in pancreatic endocrine tumors.


ABSTRACT: Little is known about the molecular anomalies involved in the development and progression of malignancy of pancreatic endocrine tumors (PETs). A recently identified member of the Ras family, Ras homologue member I (ARHI), has been shown to be involved in breast, ovary, and thyroid carcinogenesis. Unlike other members, it acts as a tumor suppressor gene that inhibits cell growth. Here we analyzed the mRNA expression of ARHI in 52 primary PETs and 16 normal pancreata using quantitative reverse transcription-polymerase chain reaction. ARHI expression showed a statistically significant difference between either normal pancreas or well-differentiated endocrine tumors (WDET) and poorly differentiated endocrine carcinomas (PDECs) (P < .001 and P < .001, respectively). Moreover, ARHI expression among WDEC samples was more heterogeneous than in WDET, with several tumors showing level of expression analogous to that observed in PDECs. A significant correlation between lower ARHI expression and shorter survival (P = .020) was identified, and a low ARHI expression was associated to a shorter time to progression (P < .001), even considering the proliferation index Ki67 in the multivariate analysis. ARHI is involved in PET progression. Its mRNA expression seemed to be a prognostic factor for disease outcome and, in association with the proliferative index Ki67, a predictor for a rapid tumor relapse.

SUBMITTER: Dalai I 

PROVIDER: S-EPMC1838575 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Low expression of ARHI is associated with shorter progression-free survival in pancreatic endocrine tumors.

Dalai Irene I   Missiaglia Edoardo E   Barbi Stefano S   Butturini Giovanni G   Doglioni Claudio C   Falconi Massimo M   Scarpa Aldo A  

Neoplasia (New York, N.Y.) 20070301 3


Little is known about the molecular anomalies involved in the development and progression of malignancy of pancreatic endocrine tumors (PETs). A recently identified member of the Ras family, Ras homologue member I (ARHI), has been shown to be involved in breast, ovary, and thyroid carcinogenesis. Unlike other members, it acts as a tumor suppressor gene that inhibits cell growth. Here we analyzed the mRNA expression of ARHI in 52 primary PETs and 16 normal pancreata using quantitative reverse tra  ...[more]

Similar Datasets

| S-EPMC5662320 | biostudies-literature
| S-EPMC5498069 | biostudies-literature
| S-EPMC6192904 | biostudies-other
| S-EPMC7467277 | biostudies-literature
| S-EPMC7588770 | biostudies-literature
| S-EPMC7596487 | biostudies-literature
| S-ECPF-TABM-48 | biostudies-other
| S-EPMC5787493 | biostudies-literature
| S-EPMC7685079 | biostudies-literature
| S-EPMC4735074 | biostudies-literature