Ontology highlight
ABSTRACT:
SUBMITTER: Yeh WI
PROVIDER: S-EPMC5662552 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in immunology 20171026
The ability to alter antigen specificity by T-cell receptor (TCR) or chimeric antigen receptor (CAR) gene transfer has facilitated personalized cellular immune therapies in cancer. Inversely, this approach can be harnessed in autoimmune settings to attenuate inflammation by redirecting the specificity of regulatory T cells (Tregs). Herein, we demonstrate efficient protocols for lentiviral gene transfer of TCRs that recognize type 1 diabetes-related autoantigens with the goal of tissue-targeted i ...[more]