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A Biocatalytic Route to Highly Enantioenriched ?-Hydroxydioxinones.

ABSTRACT: A novel biocatalytic system to access a wide variety of ?-hydroxydioxinones from ?-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in ?-hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography-free. We have demonstrated both a wide substrate scope and a high degree of scalability.

SUBMITTER: Betori RC

PROVIDER: S-EPMC5663308 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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A Biocatalytic Route to Highly Enantioenriched β-Hydroxydioxinones.

Betori Rick C RC Miller Eric R ER Scheidt Karl A KA

Advanced synthesis & catalysis 20170302 7

A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in β-hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography-free. ...[more]

PMID: 29104524

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