Ontology highlight
ABSTRACT:
SUBMITTER: Zhan Y
PROVIDER: S-EPMC5663367 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Zhan Yao Y Guo Jun J Yang William W Goncalves Christophe C Rzymski Tomasz T Dreas Agnieszka A Żyłkiewicz Eliza E Mikulski Maciej M Brzózka Krzysztof K Golas Aniela A Kong Yan Y Ma Meng M Huang Fan F Huor Bonnie B Guo Qianyu Q da Silva Sabrina Daniela SD Torres Jose J Cai Yutian Y Topisirovic Ivan I Su Jie J Bijian Krikor K Alaoui-Jamali Moulay A MA Huang Sidong S Journe Fabrice F Ghanem Ghanem E GE Miller Wilson H WH Del Rincón Sonia V SV
The Journal of clinical investigation 20171016 11
Melanoma can be stratified into unique subtypes based on distinct pathologies. The acral/mucosal melanoma subtype is characterized by aberrant and constitutive activation of the proto-oncogene receptor tyrosine kinase C-KIT, which drives tumorigenesis. Treatment of these melanoma patients with C-KIT inhibitors has proven challenging, prompting us to investigate the downstream effectors of the C-KIT receptor. We determined that C-KIT stimulates MAP kinase-interacting serine/threonine kinases 1 an ...[more]