Ontology highlight
ABSTRACT:
SUBMITTER: Winter GE
PROVIDER: S-EPMC5663500 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Winter Georg E GE Mayer Andreas A Buckley Dennis L DL Erb Michael A MA Roderick Justine E JE Vittori Sarah S Reyes Jaime M JM di Iulio Julia J Souza Amanda A Ott Christopher J CJ Roberts Justin M JM Zeid Rhamy R Scott Thomas G TG Paulk Joshiawa J Lachance Kate K Olson Calla M CM Dastjerdi Shiva S Bauer Sophie S Lin Charles Y CY Gray Nathanael S NS Kelliher Michelle A MA Churchman L Stirling LS Bradner James E JE
Molecular cell 20170629 1
Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory factors influence transcription elongation on a global scale. Prior research using small-molecule BET bromodomain inhibitors, such as JQ1, linked BRD4 to context-specific elongation at a limited number of genes associated with massive enhancer regions. Here, the mechanistic characterization of an optimized chemical degrader of BET bromodoma ...[more]