Ontology highlight
ABSTRACT:
SUBMITTER: Sakakibara Y
PROVIDER: S-EPMC5663508 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20171001 40
Development of antibiotics that target new regions of functionality is a possible way to overcome antibiotic resistance. In this study, the interactions of aminoglycoside antibiotics with helix 69 of the E. coli 23S rRNA in the context of complete 70S ribosomes or the isolated 50S subunit were investigated by using chemical probing and footprinting analysis. Helix 69 is a dynamic RNA motif that plays major roles in bacterial ribosome activity. Neomycin, paromomycin, and gentamicin interact with ...[more]