Ontology highlight
ABSTRACT:
SUBMITTER: Cao K
PROVIDER: S-EPMC5663544 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cao Ke K Li Jingjing J Chen Jia J Qian Li L Wang Aijun A Chen Xiang X Xiong Wei W Tang Jintian J Tang Shijie S Chen Yong Y Chen Yao Y Cheng Yan Y Zhou Jianda J
Oncotarget 20170705 48
Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (<i>HIF-1α</i>), a gene known to promote glycolysis. However, the role of miR-33a-5p in radiosensitivity remains to be elucidated. We found that miR-33a-5p was downregulated in melanoma tissues and cells. Cell proliferation was downregulated after overexpression of miR-33a-5p in W ...[more]