Ontology highlight
ABSTRACT:
SUBMITTER: Pan H
PROVIDER: S-EPMC2576541 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Pan Heling H Yu Jia J Zhang Lihong L Carpenter Anne A Zhu Hong H Li Li L Ma Dawei D Yuan Junying J
The Journal of biological chemistry 20080917 45
An image-based phenotypic screen was developed to identify small molecule regulators of intracellular traffic. Using this screen we found that AG1478, a previously known inhibitor of epidermal growth factor receptor, had epidermal growth factor receptor-independent activity in inducing the disassembly of the Golgi in human cells. Similar to brefeldin A (BFA), a known disrupter of the Golgi, AG1478 inhibits the activity of small GTPase ADP-ribosylation factor. Unlike BFA, AG1478 exhibits low cyto ...[more]