Using Serum IgE Antibodies to Predict Esophageal Eosinophilia in Children.

ABSTRACT:

Objectives

Symptoms of eosinophilic esophagitis are variable and can be nonspecific. Food-specific serum immunoglobulin E (IgE) antibodies are frequently found in patients with eosinophilic esophagitis and are obtained using a widely available blood test. Our objective was to evaluate the ability of food-specific IgE antibodies to predict the presence of esophageal eosinophilia.

Methods

We reviewed 144 medical records for pediatric patients having esophageal biopsy and serum analysis for IgE antibodies to food (exploratory group). We performed logistic regression using sex and number of positive food-specific IgE tests to develop a model that predicts ≥15 eosinophils/high-power field (hpf) in the esophagus. We tested the model using 142 additional patients (validation group)

SUBMITTER: Erwin EA 

PROVIDER: S-EPMC5665571 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature