Ontology highlight
ABSTRACT:
SUBMITTER: Shi X
PROVIDER: S-EPMC5665593 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Shi Xiaolei X Tasdogan Alpaslan A Huang Fang F Hu Zeping Z Morrison Sean J SJ DeBerardinis Ralph J RJ
Science advances 20171101 11
Metabolic reprogramming is a major factor in transformation, and particular metabolic phenotypes correlate with oncogenotype, tumor progression, and metastasis. By profiling metabolites in 17 patient-derived xenograft melanoma models, we identified durable metabolomic signatures that correlate with biological features of the tumors. BRAF mutant tumors had metabolomic and metabolic flux features of enhanced glycolysis compared to BRAF wild-type tumors. Tumors that metastasized efficiently from th ...[more]