Ontology highlight
ABSTRACT:
SUBMITTER: Lin MY
PROVIDER: S-EPMC5665882 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Lin Ming-Yi MY Wang Yi-Ling YL Wu Wan-Lin WL Wolseley Victoria V Tsai Ming-Ting MT Radic Vladimir V Thornton Matthew E ME Grubbs Brendan H BH Chow Robert H RH Huang I-Chueh IC
Scientific reports 20171101 1
Zika virus (ZIKV) infection is associated with microcephaly in fetuses, but the pathogenesis of ZIKV-related microcephaly is not well understood. Here we show that ZIKV infects the subventricular zone in human fetal brain tissues and that the tissue tropism broadens with the progression of gestation. Our research demonstrates also that intermediate progenitor cells (IPCs) are the main target cells for ZIKV. Post-mitotic committed neurons become susceptible to ZIKV infection as well at later stag ...[more]