Ontology highlight
ABSTRACT:
SUBMITTER: Brady SW
PROVIDER: S-EPMC5666005 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Brady Samuel W SW McQuerry Jasmine A JA Qiao Yi Y Piccolo Stephen R SR Shrestha Gajendra G Jenkins David F DF Layer Ryan M RM Pedersen Brent S BS Miller Ryan H RH Esch Amanda A Selitsky Sara R SR Parker Joel S JS Anderson Layla A LA Dalley Brian K BK Factor Rachel E RE Reddy Chakravarthy B CB Boltax Jonathan P JP Li Dean Y DY Moos Philip J PJ Gray Joe W JW Heiser Laura M LM Buys Saundra S SS Cohen Adam L AL Johnson W Evan WE Quinlan Aaron R AR Marth Gabor G Werner Theresa L TL Bild Andrea H AH
Nature communications 20171101 1
Metastatic breast cancer remains challenging to treat, and most patients ultimately progress on therapy. This acquired drug resistance is largely due to drug-refractory sub-populations (subclones) within heterogeneous tumors. Here, we track the genetic and phenotypic subclonal evolution of four breast cancers through years of treatment to better understand how breast cancers become drug-resistant. Recurrently appearing post-chemotherapy mutations are rare. However, bulk and single-cell RNA seque ...[more]