Characterization of genetic subclonal evolution in pancreatic cancer mouse models.
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ABSTRACT:
SUBMITTER: Niknafs N
PROVIDER: S-EPMC6882784 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Characterization of genetic subclonal evolution in pancreatic cancer mouse models.
Niknafs Noushin N Zhong Yi Y Moral John Alec JA Zhang Lance L Shao Melody Xiaoshan MX Lo April A Makohon-Moore Alvin A Iacobuzio-Donahue Christine A CA Karchin Rachel R
Nature communications 20191128 1
The KPC mouse model, driven by the Kras and Trp53 transgenes, is well regarded for faithful recapitulation of human pancreatic cancer biology. However, the extent that this model recapitulates the subclonal evolution of this tumor type is unknown. Here we report evidence of continuing subclonal evolution after tumor initiation that largely reflect copy number alterations that target cellular processes of established significance in human pancreatic cancer. The evolutionary trajectories of the mo ...[more]
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