Ontology highlight
ABSTRACT:
SUBMITTER: Draheim M
PROVIDER: S-EPMC5666312 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Draheim Marion M Wlodarczyk Myriam F MF Crozat Karine K Saliou Jean-Michel JM Alayi Tchilabalo Dilezitoko TD Tomavo Stanislas S Hassan Ali A Salvioni Anna A Demarta-Gatsi Claudia C Sidney John J Sette Alessandro A Dalod Marc M Berry Antoine A Silvie Olivier O Blanchard Nicolas N
EMBO molecular medicine 20171101 11
In malaria, CD4 Th1 and T follicular helper (T<sub>FH</sub>) cells are important for controlling parasite growth, but Th1 cells also contribute to immunopathology. Moreover, various regulatory CD4 T-cell subsets are critical to hamper pathology. Yet the antigen-presenting cells controlling Th functionality, as well as the antigens recognized by CD4 T cells, are largely unknown. Here, we characterize the MHC II immunopeptidome presented by DC during blood-stage malaria in mice. We establish the i ...[more]