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Spatiotemporal Control of Doxorubicin Delivery from "Stealth-Like" Prodrug Micelles.

ABSTRACT: In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, "stealth-like" doxorubicin micelles as a pro-drug delivery system, which upon light activation, leads to burst-like doxorbicin release. Through this approach, we show precise spatiotemporal control of doxorubicin delivery to cells in vitro.

SUBMITTER: Kong L

PROVIDER: S-EPMC5666715 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Spatiotemporal Control of Doxorubicin Delivery from "Stealth-Like" Prodrug Micelles.

Kong Li L Poulcharidis Dimitrios D Schneider Gregory F GF Campbell Frederick F Kros Alexander A

International journal of molecular sciences 20170922 10

In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, "stealth-like" doxorubicin micelles as a pro-drug delivery system, which upon light activation, leads to burst-like doxorbicin release. Through this approach, we show precise spatiotemporal control of doxorubicin delivery ...[more]

PMID: 28937592

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