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Progress in targeting the BCL-2 family of proteins.

ABSTRACT: The network of protein-protein interactions among the BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondrial apoptosis. Anti-apoptotic BCL-2 proteins are considered promising targets for drug discovery and exciting clinical progress has stimulated intense investigations in the broader family. Here, we discuss recent developments in small molecules targeting anti-apoptotic proteins and alternative approaches to targeting BCL-2 family interactions. These studies advance our understanding of the role of BCL-2 family proteins in physiology and disease, providing unique tools for dissecting these functions. The BCL-2 family of proteins is a prime example of targeting protein-protein interactions and further chemical biology approaches will increase opportunities for novel targeted therapies in cancer, autoimmune and aging-associated diseases.

SUBMITTER: Garner TP

PROVIDER: S-EPMC5667545 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Progress in targeting the BCL-2 family of proteins.

Garner Thomas P TP Lopez Andrea A Reyna Denis E DE Spitz Adam Z AZ Gavathiotis Evripidis E

Current opinion in chemical biology 20170817

The network of protein-protein interactions among the BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondrial apoptosis. Anti-apoptotic BCL-2 proteins are considered promising targets for drug discovery and exciting clinical progress has stimulated intense investigations in the broader family. Here, we discuss recent developments in small molecules targeting anti-apoptotic proteins and alternative approaches to targeting BCL-2 family interactions. These stud ...[more]

PMID: 28735187

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